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Normoalbuminuric diabetic kidney disease
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《医学前沿(英文)》 2017年 第11卷 第3期 页码 310-318 doi: 10.1007/s11684-017-0542-7
Diabetic kidney disease (DKD) is one of the primary causes of end-stage renal disease (ESRD). Early diagnosis is very important in preventing the development of DKD. Urinary albumin excretion rate (UAER) and glomerular filtration rate (GFR) are widely accepted as criteria for the diagnosis and clinical grading of DKD, and microalbuminuria has been recommended as the first clinical sign of DKD. The natural history of DKD has been divided into three stages: normoalbuminuria, microalbuminuria, and macroalbuminuria. However, this clinical paradigm has been questioned recently, as studies have shown that a portion of diabetes mellitus (DM) patients with normoalbuminuria have progressive renal insufficiency, referred to as normoalbuminuric diabetic kidney disease (NADKD) or nonalbuminuric diabetic nephropathy. Epidemiologic research has demonstrated that normoalbuminuric diabetic kidney disease is common, and the large number of NADKD patients suggests that the traditional paradigm needs to be shifted. Currently, the pathogenesis of NADKD remains unclear, but many clinical studies have identified some clinical and pathological features of NADKD. In addition, the long-term outcomes of NADKD patients remain controversial. In this article, we reviewed the latest studies addressing the pathogenesis, pathology, treatment and prevention of NADKD.
关键词: diabetes diabetic kidney disease normoalbuminuria renal impairment
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《医学前沿(英文)》 2012年 第6卷 第3期 页码 329-331 doi: 10.1007/s11684-012-0211-9
Ischemic postconditioning was defined as rapid intermittent interruptions of blood ?ow in the early phase of reperfusion, which has been found to be protective against renal ischemia-reperfusion injury (IRI) in animal models but not in clinical trials. We describe a case that the allograft renal vein was twisted because of the surgeon’s mistake, which caused the warm ischemia of allograft after reperfusion. The allograft restored blood flow without second reperfusion and cold preservation after 9 min of warm ischemia. The patient was followed up for 3 months and the allograft worked well without complications.
关键词: renal transplantation vein twist ischemia-reperfusion injury
Giant renal angiomyolipoma with tuberous sclerosis complex
Ouyan SHI PhD, Guodong XU BM, Chunxiang WANG BM,
《医学前沿(英文)》 2009年 第3卷 第4期 页码 495-498 doi: 10.1007/s11684-009-0068-8
关键词: renal angiomyolipoma tuberous sclerosis complex hemorrhage
Irreversible phenotypic perturbation and functional impairment of B cells during HIV-1 infection
Jingjing Yan, Shuye Zhang, Jun Sun, Jianqing Xu, Xiaoyan Zhang
《医学前沿(英文)》 2019年 第13卷 第3期 页码 409-409 doi: 10.1007/s11684-018-0618-z
Aldolase B attenuates clear cell renal cell carcinoma progression by inhibiting CtBP2
《医学前沿(英文)》 2023年 第17卷 第3期 页码 503-517 doi: 10.1007/s11684-022-0947-9
Biqiong Fu, Jie Yang, Jia Chen, Lirong Lin, Kehong Chen, Weiwei Zhang, Jianguo Zhang, Yani He
《医学前沿(英文)》 2019年 第13卷 第2期 页码 267-276 doi: 10.1007/s11684-017-0586-8
关键词: Shenkang injection senescence renal tubular epithelial cells diabetic nephropathy
Effect of renal function and hemodialysis on the serum tumor markers in patients with chronic kidney
YU Xiaofang, XU Xialian, YE Zhibin
《医学前沿(英文)》 2007年 第1卷 第3期 页码 308-311 doi: 10.1007/s11684-007-0059-6
Effect of pirfenidone on renal tubulointerstitial fibrosis
Dixin LI MM , Hongbing ZENG MD , Chunyang JI MM ,
《医学前沿(英文)》 2009年 第3卷 第3期 页码 316-322 doi: 10.1007/s11684-009-0045-2
YANG Jurong, HE Yani, SHEN Haiying, DING Hanlu, LI Kailong, WANG Huiming
《医学前沿(英文)》 2008年 第2卷 第1期 页码 25-34 doi: 10.1007/s11684-008-0006-1
Minggen YANG, Xiaokun ZHAO
《医学前沿(英文)》 2009年 第3卷 第2期 页码 191-196 doi: 10.1007/s11684-009-0026-5
SHU Ming, PENG Chenghong, CHEN Hao, SHEN Boyong, ZHOU Guangwen, SHEN Chuan, LI Hongwei
《医学前沿(英文)》 2007年 第1卷 第2期 页码 167-172 doi: 10.1007/s11684-007-0031-5
《医学前沿(英文)》 doi: 10.1007/s11684-023-1029-3
关键词: tumor prognosis molecular Microbiome subsets determine center analysis microbiome transcriptome data
evaluation of renal function using diffusion weighted imaging and diffusion tensor imaging in type 2
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《医学前沿(英文)》 2014年 第8卷 第4期 页码 471-476 doi: 10.1007/s11684-014-0365-8
This work aims to estimate the value of diffusion weighted imaging (DWI) and diffusion tensor imaging (DTI) in detecting early-stage kidney injury in type 2 diabetic patients with normoalbuminuria (NAU) versus microalbuminuria (MAU) prospectively. A total of 30 T2DM patients with normal kidney function were recruited and assigned to the NAU group (n = 14) or MAU group (n= 16) according to 8 h overnight urinary albuminuria excretion rate (AER) results. A contemporary cohort of health check-up recipients were included as controls (n = 12). DWI and DTI scans were performed on bilateral kidney using SE single-shot EPI, and apparent diffusion coefficient (ADC) and fractional anisotropy (FA) of the renal parenchyma was determined from ADC and FA maps of the three groups. ADC and FA values were compared among the three groups. According to DWI with a b value of 400 s/mm2, the MAU and NAU groups showed significantly lowered mean ADC values compared with the healthy controls (P<0.01). The mean ADC in the MAU group [(2.22±0.07)×10–3 mm2/s] was slightly lower than that of the NAU group [(2.31±0.22)×10–3 mm2/s], but this difference was not statistically significant (P>0.05). The FA value in the MAU group was higher than that in the control group (0.45±0.07 vs. 0.39±0.03, P = 0.004) but did not differ from that in the NAU group (0.42±0.03) (P>0.05). ADC and FA values may be more sensitive than urine AER in reflecting early-stage kidney injury and, hence, may facilitate earlier detection and quantitative evaluation of kidney injury in T2DM patients. Combined evaluation of ADC and FA values may provide a better quantitative approach for identifying diabetic nephropathy at early disease stages.
关键词: type 2 diabetes mellitus microalbuminuria diffusion weighted imaging diffusion tensor imaging early-stage kidney injury
Treatment of infant postrenal acute renal failure following obstruction due to upper urinary calculi
Hui-Xia ZHOU MD, Zhi-Chun FENG MD, Hao MENG MD, Xiao-Guang ZHOU MD, Shuang LI BM, Jun WANG MM, Shi-Xi DAI BM,
《医学前沿(英文)》 2010年 第4卷 第1期 页码 127-130 doi: 10.1007/s11684-010-0009-6
Clinical characteristics and outcomes of biopsy-proven diabetic nephropathy
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《医学前沿(英文)》 2017年 第11卷 第3期 页码 386-392 doi: 10.1007/s11684-017-0574-z
Kidney damage is common in patients with diabetes mellitus (DM). However, whether the type of kidney damage can be reliably diagnosed using clinical data alone remains unclear. Predictive factors for diabetic nephropathy (DN) outcomes are also poorly understood. In this study, the clinical manifestations of 111 cases of biopsy-proven DN were described, and the clinical and pathological parameters of patients with different DN outcomes were compared. Results showed that long DM duration (>10 years in 32.4% of patients), severe proteinuria (62.2%), and renal dysfunction (estimated glomerular filtration rate [eGFR]<60 mL/(min·1.73 m2)) (52.3%) did not accurately indicate whether the condition of these patients progressed to DN. Hematuria (48.6%) failed to specify either DN or nondiabetic renal disease. Diabetic retinopathy (78.4%) was a crucial complication in patients with DN. Kaplan–Meier analysis revealed that the renal survival of 53 patients who were diagnosed with DN and were followed up was not significantly associated with glomerular classification (P>0.05). Cox’s regression analysis demonstrated that renal survival time was significantly influenced by sex (b= 1.394, P= 0.038), hematuria (b= 0.036, P= 0.029), and eGFR (b= −0.039, P= 0.002) but was not significantly affected by age, 24 h urinary protein excretion, or glomerular classification (P>0.05). In conclusion, the clinical characteristics of DN vary, and renal biopsy is necessary to determine renal damage patterns. Sex, hematuria, and the eGFR may affect DN outcomes, whereas the glomerular classification may not.
关键词: diabetic nephropathy clinical characteristics renal biopsy outcomes
标题 作者 时间 类型 操作
The second short-term warm ischemia after vascular anastomosis did not affect early renal function recoveryin renal transplantation: a case report
null
期刊论文
Giant renal angiomyolipoma with tuberous sclerosis complex
Ouyan SHI PhD, Guodong XU BM, Chunxiang WANG BM,
期刊论文
Irreversible phenotypic perturbation and functional impairment of B cells during HIV-1 infection
Jingjing Yan, Shuye Zhang, Jun Sun, Jianqing Xu, Xiaoyan Zhang
期刊论文
Preventive effect of Shenkang injection against high glucose-induced senescence of renal tubular cells
Biqiong Fu, Jie Yang, Jia Chen, Lirong Lin, Kehong Chen, Weiwei Zhang, Jianguo Zhang, Yani He
期刊论文
Effect of renal function and hemodialysis on the serum tumor markers in patients with chronic kidney
YU Xiaofang, XU Xialian, YE Zhibin
期刊论文
Effect of pirfenidone on renal tubulointerstitial fibrosis
Dixin LI MM , Hongbing ZENG MD , Chunyang JI MM ,
期刊论文
Expression of renal cubilin and its potential role in tubulointerstitial inflammation induced by albumin
YANG Jurong, HE Yani, SHEN Haiying, DING Hanlu, LI Kailong, WANG Huiming
期刊论文
Retrospective study of the efficacy and complication of thoracoabdominal incision for nephrectomy: a comparison with flank approach
Minggen YANG, Xiaokun ZHAO
期刊论文
Intra-abdominal hypertension is an independent cause of acute renal failure after orthotopic liver transplantation
SHU Ming, PENG Chenghong, CHEN Hao, SHEN Boyong, ZHOU Guangwen, SHEN Chuan, LI Hongwei
期刊论文
Microbiome subsets determine tumor prognosis and molecular characteristics of clear-cell renal cell carcinoma
期刊论文
evaluation of renal function using diffusion weighted imaging and diffusion tensor imaging in type 2
null
期刊论文
Treatment of infant postrenal acute renal failure following obstruction due to upper urinary calculi
Hui-Xia ZHOU MD, Zhi-Chun FENG MD, Hao MENG MD, Xiao-Guang ZHOU MD, Shuang LI BM, Jun WANG MM, Shi-Xi DAI BM,
期刊论文